PROPOSED MECHANISM FOR PRODUCTION OF STABLE AMINOXYL RADICAL IMPURITIES IN THE SYNTHESIS OF SUBSTITUTED 5,5-DIMETHYLPYRROLINE-N-OXIDE (DMPO) SPIN TRAPS

被引：10

作者：

JANZEN, EG

ZHANG, YK

ARIMURA, M

机构：

[1] UNIV GUELPH, ONTARIO VET COLL, DEPT CLIN MED, GUELPH N1G 2W1, ONTARIO, CANADA

[2] UNIV GUELPH, ONTARIO VET COLL, DEPT BIOMED SCI, GUELPH N1G 2W1, ONTARIO, CANADA

来源：

CHEMISTRY LETTERS | 1993年 / 03期

关键词：

D O I：

10.1246/cl.1993.497

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Paramagnetic impurities in nitrone spin traps are bothering researchers in the practice of spin trapping. By use of mass spectroscopy, a hydroxylamine dimer of 2,5,5-trimethylpyrroline-N-oxide (M3PO) has been found in samples of M3PO. Air oxidation of the hydroxylamine may produce the aminoxyl radical impurity detected. Mechanisms for the generation of impurities in DMPO and derivatives are proposed.

引用

页码：497 / 500

页数：4

共 16 条

[1]

ARIMURA M, UNPUB

[2]

Banfield FH, 1926, J CHEM SOC, P1612

[3]

CAREY FA, 1977, ADV ORGANIC CHEM B, P220

[4]

Forrester A. R., 1968, ORGANIC CHEM STABLE, P180