A ROLE FOR EXONUCLEASE-I FROM S-POMBE IN MUTATION AVOIDANCE AND MISMATCH CORRECTION

被引：179

作者：

SZANKASI, P ^{[1
]}

SMITH, GR ^{[1
]}

机构：

[1] FRED HUTCHINSON CANC RES CTR,SEATTLE,WA 98104

来源：

SCIENCE | 1995年 / 267卷 / 5201期

关键词：

D O I：

10.1126/science.7855597

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Exonuclease I (Exo I) from Schizosaccharomyces pombe, a 5' --> 3' double-stranded DNA exonuclease, is induced during meiotic prophase I. The exo1 gene is a member of a family of related DNA repair genes, including RAD2/rad13/xpgc and YKL510/rad2, conserved from yeast to humans. An exo1 mutant displays a mutator phenotype and alters activity of the ade6-M387 marker effect. These results suggest that Exo I acts in a pathway that corrects mismatched base pairs.

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页码：1166 / 1169

页数：4

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