INHIBITORS OF ESTROGEN BIOSYNTHESIS - PRECLINICAL STUDIES WITH CGS 16949A, A NEW NONSTEROIDAL AROMATASE INHIBITOR

被引:28
作者
BHATNAGAR, AS [1 ]
SCHIEWECK, K [1 ]
HAUSLER, A [1 ]
BROWNE, LJ [1 ]
STEELE, RE [1 ]
机构
[1] CIBA GEIGY CORP,DIV PHARMACOL,RES DEPT,SUMMIT,NJ 07901
来源
PROCEEDINGS OF THE ROYAL SOCIETY OF EDINBURGH SECTION B-BIOLOGICAL SCIENCES | 1989年 / 95卷
关键词
D O I
10.1017/S0269727000010769
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:293 / 303
页数:11
相关论文
共 19 条
[1]   EFFECT OF AN AROMATASE INHIBITOR, 4-HYDROXY-4-ANDROSTENE-3,17-DIONE, ON ESTROGEN-DEPENDENT PROCESSES IN REPRODUCTION AND BREAST-CANCER [J].
BRODIE, AMH ;
SCHWARZEL, WC ;
SHAIKH, AA ;
BRODIE, HJ .
ENDOCRINOLOGY, 1977, 100 (06) :1684-1695
[2]   STUDIES ON MECHANISM OF ESTROGEN BIOSYNTHESIS IN RAT OVARY .1. [J].
BRODIE, AMH ;
SCHWARZEL, WC ;
BRODIE, HJ .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1976, 7 (10) :787-793
[3]  
BROWNE LJ, 1986, 9 INT S MED CHEM BER
[4]   SYNTHESIS AND BIOCHEMICAL EVALUATION OF ANALOGS OF AMINOGLUTETHIMIDE BASED ON PHENYLPYRROLIDINE-2,5-DIONE [J].
DALY, MJ ;
JONES, GW ;
NICHOLLS, PJ ;
SMITH, HJ ;
ROWLANDS, MG .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (04) :520-523
[5]   EFFECT OF OVARIECTOMY, TAMOXIFEN AND COMBINATION ADRIAMYCIN AND 5-FU ON 7,12-DIMETHYLBENZA(A)ANTHRACENE INDUCED MAMMARY-CANCER OF RAT [J].
FIEBIG, HH ;
SCHMAHL, D .
ONCOLOGY, 1977, 34 (02) :58-61
[6]   SOURCE OF ESTROGEN PRODUCTION IN POSTMENOPAUSAL WOMEN [J].
GRODIN, JM ;
SIITERI, PK ;
MACDONALD, PC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 36 (02) :207-214
[7]   AROMATASE INHIBITORS - SYNTHESIS AND EVALUATION OF MAMMARY-TUMOR INHIBITING ACTIVITY OF 3-ALKYLATED 3-(4-AMINOPHENYL) PIPERIDINE-2,6-DIONES [J].
HARTMANN, RW ;
BATZL, C .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (08) :1362-1369
[8]  
HAUSLER A, 1989, IN PRESS J STEROID B
[9]   1-METHYL-1,4-ANDROSTADIENE-3,17-DIONE (SH 489) - CHARACTERIZATION OF AN IRREVERSIBLE INHIBITOR OF ESTROGEN BIOSYNTHESIS [J].
HENDERSON, D ;
NORBISRATH, G ;
KERB, U .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1986, 24 (01) :303-306
[10]  
JORDAN VC, 1976, CANCER TREAT REP, V60, P1409