BIOGENETIC RELATIONSHIP OF POLYOXYGENATED DITERPENES IN COLEUS-FORSKOHLII

被引：7

作者：

AKHILA, A

RANI, K

THAKUR, RS

机构：

[1] Central Institute of Medicinal and Aromatic Plants, Lucknow

来源：

PHYTOCHEMISTRY | 1990年 / 29卷 / 03期

关键词：

biosynthesis; Coleus forskohlii; diterpenes; forskolin; Labiatae;

D O I：

10.1016/0031-9422(90)80026-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The isotopic and atomic 14C/3H ratios obtained for polyoxygenated diterpenes isolated from the roots of Coleus forskohlii, that had been fed with [2-14C,2-3H2]-, [2-4C,4R-3H1]-, [2-14C,5-3H2]MVA, revealed that 8,13-epoxy-labd-14-en-11-one is the first mono-oxygenated labdane-type diterpene to be formed on the biosynthetic pathway leading from the labdane-diterpene skeleton. Subsequent sequential addition of oxygen gives 1,9-dideoxyfor-skolin, 9-deoxyforskolin and forskolin, along with many other diterpenes. Forskolin is the last compound to be formed in the biogenetic sequence. © 1990.

引用

页码：821 / 824

页数：4

共 17 条

[1] TERPENE BIOSYNTHESIS .13. METABOLIC POOLS ASSOCIATED WITH MONOTERPENE BIOSYNTHESIS IN HIGHER-PLANTS [J].