INFLUENCE OF THE STRUCTURE OF CHEMICALLY BONDED C-18 PHASES ON HPLC SEPARATION OF NAPROXEN GLUCURONIDE DIASTEREOISOMERS

被引：7

作者：

BUSZEWSKI, B

ELMOUELHI, M

ALBERT, K

BAYER, E

机构：

[1] INST ORGAN CHEM,W-7400 TUBINGEN,GERMANY

[2] UNIV TUBINGEN,INST TOXIKOL,W-7400 TUBINGEN 1,GERMANY

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 03期

关键词：

D O I：

10.1080/01483919008051802

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

On the basis of Nucleosil-100 a series of materials with varying structure and different coverage density of chemically bonded C18 phases (CBP) were prepared. The physico-chemical characteristics of these packings e.g. porosity and carbon content were studied by the BET method and CHN analysis. The structure of the C18 CBP was determined by solid state CP/MAS NMR. The prepared packings and columns have been applied for HPLC separation of naproxen and its two diastereoisomeric conjugates with glucuronic acid. Material with monomeric C18 CBP structure and with high coverage density has given good and reproducible separation results. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：505 / 524

页数：20

共 18 条

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