ISOLATION-INDUCED CHANGES IN RADIOLIGAND BINDING TO BENZODIAZEPINE BINDING-SITES

被引：22

作者：

MIACHON, S

MANCHON, M

FROMENTIN, JR

BUDA, M

机构：

[1] INSERM U 171-CNRS UA 95, Centre Hospitalier Lyon Sud, Pierre Benite

来源：

NEUROSCIENCE LETTERS | 1990年 / 111卷 / 03期

关键词：

Benzodiazepine binding; Isolated male Wistar rat; γ-Aminobutyric acid;

D O I：

10.1016/0304-3940(90)90269-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Binding of [3H]flunitrazepam was studied in brain tissues of isolated Wistar rats and compared to group-reared animals. Modifications were observed in hippocampus and cortex (Kd increased) and in cerebellum (Bmax decreased) and when brain sections of control rats were incubated in the bath fluid that had served to incubate sections from isolated rats, a flattening of the saturation curve was observed. Results are discussed in terms of possible modulators of benzodiazepine binding sites, mainly tissue GABA concentrations. © 1990.

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页码：246 / 251

页数：6

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