CARBAMAZEPINE VS PHENYTOIN - CONTROLLED CLINICAL-TRIAL IN FOCAL MOTOR AND GENERALIZED EPILEPSY

被引：42

作者：

KOSTELJANETZ, M ^{[1
]}

CHRISTIANSEN, J ^{[1
]}

DAM, AM ^{[1
]}

HANSEN, BS ^{[1
]}

LYON, BB ^{[1
]}

PEDERSEN, H ^{[1
]}

DAM, M ^{[1
]}

机构：

[1] HVIDOVRE HOSP, UNIV CLIN NEUROL, DK-2650 HVIDOVRE, DENMARK

来源：

ARCHIVES OF NEUROLOGY | 1979年 / 36卷 / 01期

关键词：

D O I：

10.1001/archneur.1979.00500370052010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The antiepileptic effects of carbamazepine and phenytoin were compared in a double-blind crossover trial studying patients with primary and secondary generalized seizures and partial seizures with motor symptoms. Each treatment period lasted ten weeks. The patients were seen every two weeks, and doses were adjusted according to plasma levels. It was attempted to keep levels in the optimal plasma range, ie, 10 to 20 and 4 to 10 mg/liter for phenytoin and carbamazepine, respectively. Twenty-three patients entered and 19 completed the study. No statistically significant differences were found between carbamazepine and phenytoin with regard to seizure control and acute side effects. © 1979, American Medical Association. All rights reserved.

引用

页码：22 / 24

页数：3

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