POTENT CONSTRICTION OF CAT CORONARY-ARTERIES BY HYDROPEROXIDES OF ARACHIDONIC-ACID AND ITS BLOCKADE BY ANTI-INFLAMMATORY AGENTS

The ω-6 and ω-9 hydroperoxides of arachidonic acid caused dose-dependent constriction of cat coronary arteries in concentrations of 10-8 to 10-5M. Their potency was comparable to that of prostaglandin (PG) E2, and PGF2α and 100 times greater than that of arachidonic acid. The cyclooxygenase inhibitor, meclofenamate markedly reduced constriction caused by the hydroperoxides but potentiated constriction caused by the prostaglandins. The effects of the hydroperoxides were also reduced by indomethacin and dexamethasone but were unaffected by the thromboxane synthetase inhibitor imidazole. Since the hydroperoxides are not substrates for cyclooxygenase, it is suggested that they have a direct effect on the arteries which can be antagonized by anti-inflammatory drugs. © 1980.