EXPRESSION OF INTERCELLULAR-ADHESION MOLECULE-1 ON RAT MICROGLIAL CELLS

被引：30

作者：

ZIELASEK, J

ARCHELOS, JJ

TOYKA, KV

HARTUNG, HP

机构：

[1] Department of Neurology, Multiple Sclerosis Clinical Research Group, Julius-Maximilians Universität Würzburg

来源：

NEUROSCIENCE LETTERS | 1993年 / 153卷 / 02期

关键词：

MICROGLIAL CELL; LEUKOCYTE ADHESION MOLECULE; GAMMA-INTERFERON; TUMOR NECROSIS FACTOR-ALPHA; MULTIPLE SCLEROSIS; INFLAMMATION;

D O I：

10.1016/0304-3940(93)90306-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglial cells isolated from newborn rat brain displayed a baseline immunoreactivity for intercellular adhesion molecule-1 (ICAM-1) after 10-20 days in culture. ICAM-1 immunoreactivity was enhanced in a time-dependent fashion by exposing the microglial cells to recombinant rat gamma-interferon (gamma-IFN; 100 U/ml) or tumor necrosis factor-alpha (TNF-alpha; 1000 U/ml). We conclude that rat brain macrophages/microgliaI cells can be induced by gamma-IFN and TNF-alpha to express ICAM-1. This may be relevant in the interaction of microglial cells with other brain cells during inflammation of the central nervous system.

引用

页码：136 / 139

页数：4

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