LEVELS OF NON-ORTHO-SUBSTITUTED (COPLANAR), MONO-ORTHO-SUBSTITUTED AND DI-ORTHO-SUBSTITUTED POLYCHLORINATED-BIPHENYLS, DIBENZO-P-DIOXINS, AND DIBENZOFURANS IN HUMAN SERUM AND ADIPOSE-TISSUE

被引:99
作者
PATTERSON, DG
TODD, GD
TURNER, WE
MAGGIO, V
ALEXANDER, LR
NEEDHAM, LL
机构
关键词
D O I
10.1289/ehp.94102s1195
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
We have measured non-ortho-substituted (coplanar) polychlorinated biphenyl (PCB) levels as well as polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) levels in human adipose tissue and serum collected in Atlanta, Georgia. The results show that the concentrations of the coplanar PCBs can be more than an order of magnitude higher than the concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Our measurements in pooled serum collected in 1982, 1988, and 1989 show a decrease in coplanar PCB levels from 1982 to 1989. We found that the pattern of relative amounts of coplanar PCBs in adipose tissue varied greatly from person to person unlike the PCDD and PCDF patterns, which were more nearly the same. Age was significantly correlated with the concentrations of 2,3,7,8-TCDD,3,3'4,4'-PCB, 3,3',4,4',5-PCB, and 3,3'4,4',5,5'-PCB in adipose tissue. We also measured levels of the mono- and di-ortho chlorine-substituted PCBs in human serum. The levels for some of these PCB congeners were three orders of magnitude higher than the coplanar PCBs, PCDDs, and PCDFs. We used the international toxicity equivalency factors (TEFs) for PCDDs and PCDFs and the TEFs proposed by Safe for PCBs to calculate the 2,3,7,8-TCDD equivalents. Four PCBs (3,3',4,4',5-; 2,3',4,4',5-;2,3,3',4,4'-;2,3,3',4,4',5-) make a larger contribution than 2,3,7,8-TCDD, while four other PCBs (3,3',4,4'5,5'-; 2,2',3,4,4',5'-;2,2',4,4',5,5'-;2,2',3,4,4',5,5'-) make nearly the same contribution as 2,3,7,8-TCDD. The mono-ortho-chlorine-substituted 2,3',4,4',5-PCB, however, is the major contributor to the total 2,3,7,8-TCDD equivalents in general population samples from the United States, Sweden, and Japan. The PCDDs are the second most significant contributor in the U.S. samples, whereas the coplanar PCBs are the second most significant contributor in samples from Sweden and Japan.
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页码:195 / 204
页数:10
相关论文
共 61 条
[1]   COMPARATIVE-STUDY OF 3,4,3',4'-TETRACHLOROBIPHENYL IN MALE AND FEMALE RATS AND FEMALE MONKEYS [J].
ABDELHAMID, FM ;
MOORE, JA ;
MATTHEWS, HB .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1981, 7 (02) :181-191
[2]   THE ESTIMATION OF TOTAL SERUM-LIPIDS BY A COMPLETELY ENZYMATIC SUMMATION METHOD [J].
AKINS, JR ;
WALDREP, K ;
BERNERT, JT .
CLINICA CHIMICA ACTA, 1989, 184 (03) :219-226
[3]   ANALYSIS OF NON-ORTHO POLYCHLORINATED-BIPHENYLS AND POLYCHLORINATED NAPHTHALENES IN SWEDISH DIOXIN SURVEY SAMPLES [J].
ASPLUND, L ;
GRAFSTROM, AK ;
HAGLUND, P ;
JANSSON, B ;
JARNBERG, U ;
MACE, D ;
STRANDELL, M ;
DEWIT, C .
CHEMOSPHERE, 1990, 20 (10-12) :1481-1488
[4]   ANALYSIS OF POLYCHLORINATED-BIPHENYLS (PCB) BY GLASS-CAPILLARY GAS-CHROMATOGRAPHY - COMPOSITION OF TECHNICAL AROCLOR-PCB AND CLOPHEN-PCB MIXTURES [J].
BALLSCHMITER, K ;
ZELL, M .
FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1980, 302 (01) :20-31
[5]   STUDIES OF THE GLOBAL BASELINE POLLUTION .5. MONITORING THE BASELINE POLLUTION OF THE SUB-ANTARCTIC BY PENGUINS AS BIOINDICATORS [J].
BALLSCHMITER, K ;
SCHOLZ, C ;
BUCHERT, H ;
ZELL, M ;
FIGGE, K ;
POLZHOFER, K ;
HOERSCHELMANN, H .
FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1981, 309 (01) :1-7
[6]   3,3',4,4'-TETRACHLOROBIPHENYL IN HUMAN FAT AND MILK SAMPLES [J].
BECK, H ;
DROSS, A ;
MATHAR, W .
CHEMOSPHERE, 1989, 19 (12) :1805-1810
[7]   USE OF REFERENCE POOLS TO COMPARE THE QUALITATIVE AND QUANTITATIVE-DETERMINATION OF POLYCHLORINATED-BIPHENYLS BY PACKED AND CAPILLARY GAS-CHROMATOGRAPHY WITH ELECTRON-CAPTURE DETECTION .1. SERUM [J].
BURSE, VW ;
GROCE, DF ;
KORVER, MP ;
MCCLURE, PC ;
HEAD, SL ;
NEEDHAM, LL ;
LAPEZA, CR ;
SMREK, AL .
ANALYST, 1990, 115 (03) :243-251
[8]  
DEWAILLY E, 1989, 9TH INT S CHLOR DIOX
[9]  
DEWAILLY E, 1990, ORGANOHALOGEN COMPOU, V1, P227
[10]   APPLICATION OF A DUAL COLUMN REACTION CHROMATOGRAPHY SYSTEM FOR CONFIRMATORY ANALYSIS OF POLYCHLORINATED BIPHENYL CONGENERS [J].
DUEBELBEIS, DO ;
PIECZONKA, G ;
KAPILA, S ;
CLEVENGER, TE ;
YANDERS, AF ;
WILSON, JD .
CHEMOSPHERE, 1989, 19 (1-6) :143-148