CYCLOPROPAMITOSENES, NOVEL BIOREDUCTIVE ANTICANCER AGENTS - SYNTHESIS OF 7-METHOXYCYCLOPROPAMITOSENE AND RELATED INDOLEQUINONES

被引:39
作者
COTTERILL, AS [1 ]
HARTOPP, P [1 ]
JONES, GB [1 ]
MOODY, CJ [1 ]
NORTON, CL [1 ]
OSULLIVAN, N [1 ]
SWANN, E [1 ]
机构
[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,DEPT CHEM,LONDON SW7 2AY,ENGLAND
关键词
D O I
10.1016/S0040-4020(01)90492-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of the 7-methoxy-1,2-cyclopropapyrrolo[1,2-a]indoles (cyclopropamitosenes) 5 and the related indolequinone 6 is described.
引用
收藏
页码:7657 / 7674
页数:18
相关论文
共 37 条
[1]  
BLACKBURN GM, 1990, NUCLEIC ACIDS CHEM B
[2]   DUPLEX OLIGODEOXYRIBONUCLEOTIDES CROSS-LINKED BY MITOMYCIN-C AT A SINGLE SITE - SYNTHESIS, PROPERTIES, AND CROSS-LINK REVERSIBILITY [J].
BOROWYBOROWSKI, H ;
LIPMAN, R ;
CHOWDARY, D ;
TOMASZ, M .
BIOCHEMISTRY, 1990, 29 (12) :2992-2999
[3]   RECOGNITION BETWEEN MITOMYCIN-C AND SPECIFIC DNA-SEQUENCES FOR CROSS-LINK FORMATION [J].
BOROWYBOROWSKI, H ;
LIPMAN, R ;
TOMASZ, M .
BIOCHEMISTRY, 1990, 29 (12) :2999-3006
[4]  
CARTER SK, 1979, MITOMYCIN C CURRENT
[5]   ON THE CHARACTERIZATION OF INTERMEDIATES IN THE MITOMYCIN ACTIVATION CASCADE - A PRACTICAL SYNTHESIS OF AN AZIRIDINOMITOSENE [J].
DANISHEFSKY, SJ ;
EGBERTSON, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (15) :4648-4650
[6]   ON THE REMARKABLE STABILITY OF DERIVATIVES OF LEUCOMITOMYCIN-F - NOVEL MITOMYCIN ANALOGS [J].
EGBERTSON, M ;
DANISHEFSKY, SJ ;
SCHULTE, G .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (19) :4424-4426
[7]   MODELING OF THE ELECTROPHILIC ACTIVATION OF MITOMYCINS - CHEMICAL EVIDENCE FOR THE INTERMEDIACY OF A MITOSENE SEMIQUINONE AS THE ACTIVE ELECTROPHILE [J].
EGBERTSON, M ;
DANISHEFSKY, SJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (07) :2204-2205
[8]   PYRROLO(1,2-ALPHA)INDOLE CHEMISTRY . REACTIONS OF A TRIDENTATE CARBANION [J].
FRANCK, RW ;
BERNADY, KF .
JOURNAL OF ORGANIC CHEMISTRY, 1968, 33 (08) :3050-&
[9]  
FRANCK RW, 1990, CHEM ANTITUMOR AGENT, P379
[10]  
Giese B., 1986, RADICALS ORGANIC SYN