ASSESSMENT OF NEURONAL DENSITY IN THE PUTAMEN IN HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION - APPLICATION OF STEREOLOGY AND SPATIAL-ANALYSIS OF QUADRATS

被引：34

作者：

EVERALL, I

BARNES, H

SPARGO, E

LANTOS, P

机构：

[1] Department of Neuropathology, Institute of Psychiotry, De Crespigny Park, London

来源：

JOURNAL OF NEUROVIROLOGY | 1995年 / 1卷 / 01期

关键词：

HIV; PUTAMEN; SPATIAL ANALYSIS; ANALYSIS OF QUADRATS; NEURONAL CLUSTERING; NEURONAL;

D O I：

10.3109/13550289509111017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human immunodeficiency virus causes neuronal loss in various brain regions, but it has not been reported in the putamen. However, decrease in the volume of the putamen has been observed by magnetic resonance imaging. In order to clarify this issue two complementary methods: the stereological probe, the disector, and spatial analysis of quadrats, were applied in nondemented individuals who had died of acquired immune deficiency syndrome. A 21% decrease in neuronal density was observed in the human immunodeficiency virus group, especially those cases with human immunodeficiency virus encephalitis; however the statistical significance of this finding was borderline.

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页码：126 / 129

页数：4

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