INDIRECT GENE DIAGNOSES FOR COMPLEX (MULTIFACTORIAL) DISEASES - A REVIEW

被引：8

作者：

EPPLEN, JT ^{[1
]}

BUITKAMP, J ^{[1
]}

BOCKER, T ^{[1
]}

EPPLEN, C ^{[1
]}

机构：

[1] UNIV REGENSBURG,INST PATHOL,D-93042 REGENSBURG,GERMANY

来源：

GENE | 1995年 / 159卷 / 01期

关键词：

SIMPLE REPETITIVE DNA; MULTILOCUS DNA FINGERPRINTING; MICROSATELLITES; DNA PROFILING; GENOME SCANNING; IMMUNOPRINTING; DISEASE ASSOCIATIONS;

D O I：

10.1016/0378-1119(94)00535-Z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The analysis of multifactorial diseases requires the efficient investigation of large numbers of (gene) loci and patient (family) samples. Since simple repetitive DNA markers are dispersed all over the chromosomes; molecular techniques employing these tools render most conventional screening procedures obsolete. Examples of tumors, autoimmune diseases and infections are presented to validate concepts of indirect gene diagnoses via simple, tandemly arranged, repetitive DNA sequences. The salient advantages of microsatellite technologies vs. those of multilocus DNA fingerprinting are weighed.

引用

页码：49 / 55

页数：7

共 48 条

[1] CLUES TO THE PATHOGENESIS OF FAMILIAL COLORECTAL-CANCER
AALTONEN, LA
PELTOMAKI, P
LEACH, FS
SISTONEN, P
PYLKKANEN, L
MECKLIN, JP
JARVINEN, H
POWELL, SM
JEN, J
HAMILTON, SR
PETERSEN, GM
KINZLER, KW
VOGELSTEIN, B
DELACHAPELLE, A
[J]. SCIENCE, 1993, 260 (5109) : 812 - 816
[2] BECKMANN JS, 1982, BIOTECHNOLOGY, V5, P573
[3] DETECTION OF SOMATIC CHANGES IN HUMAN RENAL-CELL CARCINOMAS WITH OLIGONUCLEOTIDE PROBES SPECIFIC FOR SIMPLE REPEAT MOTIFS
BOCK, S
EPPLEN, JT
NOLLPUCHTA, H
ROTTER, M
HOFLER, H
BLOCK, T
HARTUNG, R
JAKSE, G
WILMANNS, W
PETRIDES, PE
[J]. GENES CHROMOSOMES & CANCER, 1993, 6 (02) : 113 - 117
[4] Bocker Tina, 1994, Pathology Research and Practice, V190, P265
[5] THE CYTOKINE WALL CHART
BURKE, F
NAYLOR, MS
DAVIES, B
BALKWILL, F
[J]. IMMUNOLOGY TODAY, 1993, 14 (04): : 165 - 170
[6] COOKSON WOCM, 1989, LANCET, V1, P1292
[7] ANTHELMINTIC RESISTANCE
CRAIG, TM
[J]. VETERINARY PARASITOLOGY, 1993, 46 (1-4) : 121 - 131
[8] DAY CE, 1994, IMMUNOGENETICS, V39, P335
[9] FUNCTIONAL-CHARACTERIZATION OF THE PROMOTER FOR THE HUMAN GERM-LINE T-CELL RECEPTOR J-ALPHA (TEA) TRANSCRIPT
DECHASSEVAL, R
DEVILLARTAY, JP
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (06) : 1294 - 1298
[10] ABOLITION OF ANAPHYLAXIS BY TARGETED DISRUPTION OF THE HIGH-AFFINITY IMMUNOGLOBULIN-E RECEPTOR ALPHA-CHAIN GENE
DOMBROWICZ, D
FLAMAND, V
BRIGMAN, KK
KOLLER, BH
KINET, JP
[J]. CELL, 1993, 75 (05) : 969 - 976

← 1 2 3 4 5 →