CORRELATIONS BETWEEN AQUEOUS FLARE AND CELLS AND LENS SURFACE CYTOLOGY IN EYES WITH POLY(METHYL METHACRYLATE) AND HEPARIN-SURFACE-MODIFIED INTRAOCULAR LENSES

被引：29

作者：

PANDE, M ^{[1
]}

SHAH, SM ^{[1
]}

SPALTON, DJ ^{[1
]}

机构：

[1] ST THOMAS HOSP,DEPT OPHTHALMOL,LONDON SE1 7EH,ENGLAND

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 1995年 / 21卷 / 03期

关键词：

BIOCOMPATIBILITY; CORRELATION; FLARE; GIANT CELL; HEPARIN SURFACE MODIFIED LENS; SMALL CELL;

D O I：

10.1016/S0886-3350(13)80142-3

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A prospective, single-surgeon study was performed on 59 patients randomized to receive a poly(methyl methacrylate) intraocular lens or a heparin-surface-modified lens after standardized endocapsular cataract surgery with a routine postoperative regimen. The anterior chamber laser flare and cell measurements and the cellular reaction on the anterior lens surface were monitored for a year following surgery. This report examines the correlations between the anterior chamber flare and cell reaction and the anterior IOL surface cellular reaction. The findings suggest that the early postoperative blood-aqueous barrier breakdown is primarily caused by surgical trauma; by one month the blood-aqueous barrier function is determined by inflammatory mediators released by small monocyte-derived cells on the IOL surface. Giant cells on the IOL surface did not correlate with aqueous flare, which suggests an insignificant capacity to release inflammatory mediators.

引用

页码：326 / 330

页数：5

共 31 条

[1]

Apple DJ, Mamalis N, Loftfield K, Et al., Complications of intraocular lenses, A historical and histopathological review. Surv Ophthalmol, 29, pp. 1-54, (1984)

[2]

Hogan MJ, Kimura SJ, Thygeson P, Signs and symptoms of uveitis, 1, American Journal of Ophthalmology, 47, 5, pp. 155-170, (1959)

[3]

Ferguson VMG, Spalton DJ, Recovery of the bloodaqueous barrier after cataract surgery, Br J Ophthalmol, 75, pp. 106-110, (1991)

[4]

Sawa M, Sakanishi Y, Shimizu H, Fluorophotometric study of anterior segment barrier functions after extracapsular cataract extraction and posterior chamber intraocular lens implantation, Am J Ophthalmol, 97, pp. 197-204, (1984)

[5]

Sawa M, Tsurimaki Y, Tsuru T, Shimizu H, New quantitative method to determine protein concentration and cell number in aqueous in vivo, Jpn J Ophthalmol, 32, pp. 132-142, (1988)

[6]

Shah SM, Spalton DJ, Smith SE, Measurement of aqueous cells and flare in normal eyes, Br J Ophthalmol, 75, pp. 348-352, (1991)

[7]

El-Maghraby A, Marzouki A, Matheen TM, Et al., Reproducibility and validity of laser flare/cell meter measurements of intraocular inflammation, J Cataract Refract Surg, 19, pp. 52-55, (1993)

[8]

Ohara K, Biomicroscopy of surface deposits resembling foreign-body giant cells on implanted intraocular lenses, Am J Ophthalmol, 99, pp. 304-311, (1985)

[9]

Sievers H, von Domarus D, Foreign-body reaction against intraocular lenses, Am J Ophthalmol, 97, pp. 743-751, (1984)

[10]

Wenzel M, Reim M, Heinze M, Bocking A, Cellular invasion on the surface of intraocular lenses, In vivo cytological observations following lens implantation. Graefes Arch Clin Exp Ophthalmol, 226, pp. 449-454, (1988)

← 1 2 3 4 →