TUMORIGENESIS WITH ISONICOTINIC ACID HYDRAZIDE AND URETHAN IN SYRIAN GOLDEN HAMSTERS

被引：24

作者：

TOTH, B

BOREISHA, I

机构：

[1] The Eppley Institute for Research in Cancer, University of Nebraska College of Medicine, Omaha, NE 68105

来源：

EUROPEAN JOURNAL OF CANCER | 1969年 / 5卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0014-2964(69)90064-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Solutions of 0·1% of isonicotinic acid hydrazide and urethan were given alone and also jointly in the drinking water to 5-week old Syrian golden hamsters for the remainder of their lifetime. The urethan-administration resulted in the induction of dermal melanocytomas, papillomas and carcinomas of forestomach, adenomatous polyps of caecum, pulmonary adenomatoses and various other types of tumors. Isonicotinic acid hydrazide-treatment alone was without any apparent carcinogenic effect, and the simultaneous isonicotinic acid hydrazide and urethan treatments gave rise to no significantly higher incidences of tumors than what resulted by either chemicals alone. The selective carcinogenicity of isonicotinic acid hydrazide in the various species are discussed in the light of the results obtained. © 1969.

引用

页码：165 / &

共 17 条

[1] PULMONARY TUMOURS IN MICE INDUCED BY ORAL ISONIAZID AND ITS METABOLITES [J].