HUMORAL FACTOR THAT SPECIFICALLY REGULATES PROTHROMBIN (FACTOR-II) LEVELS (COAGULOPOIETIN-II)

被引：17

作者：

KARPATKIN, M ^{[1
]}

KARPATKIN, S ^{[1
]}

机构：

[1] NYU,SCH MED,DEPT MED,NEW YORK,NY 10016

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 01期

关键词：

D O I：

10.1073/pnas.76.1.491

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prothrombin (Factor II) was decreased in rabbits by injection of a goat antiserum to prothrombin. When plasma from these rabbits was injected into normal animals, circulating prothrombin increased in the recipients, suggesting transfer of a humoral regulating factor ('coagulopoietin-II'). this coagulopoietin-II resisted boiling for 20 min. On Sephadex G-50 gel filtration, it remained in the retained volume, suggesting a molecular weight of less than 30,000. In an in vitro liver system, protrombin increased in the incubation medium in the presence of coagulopoietin-II.

引用

页码：491 / 493

页数：3

共 8 条

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (07) :2730-2733

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