1. 1. The criteria used for clinical and histopathologic changes in leukoplakia are given in detail. 2. 2. This is a 5-year follow-up study of 3,785 men out of an initial group of 4,734 who were examined in 1959. 3. 3. A detailed clinicopathologic correlation is presented. 4. 4. A correlation of the clinical appearance of the lesions with the habits indulged in is presented. 5. 5. No malignant transformation of leukoplakia lesion was reported after a 5-year follow-up study, and no lesions diagnosed as clinical leukoplakia were found to be carcinoma in situ. 6. 6. Of 161 leukoplakia cases, twenty cases were histologically diagnosed as atypias. 7. 7. The homogeneous type of leukoplakia accounted for only 3.7 per cent of the atypias, while the speckled accounted for 8.6 per cent. 8. 8. Bidi smoking, pan chewing, and mixed habits are significantly responsible for leukoplakias, in the descending order of importance. © 1969.
