SUPRACRYSTALLOGRAPHIC RESOLUTION OF INTERACTIONS CONTRIBUTING TO ENZYME CATALYSIS BY USE OF NATURAL STRUCTURAL VARIANTS AND REACTIVITY-PROBE KINETICS

被引：42

作者：

BROCKLEHURST, K

BROCKLEHURST, SM

KOWLESSUR, D

ODRISCOLL, M

PATEL, G

SALIH, E

TEMPLETON, W

THOMAS, E

TOPHAM, CM

WILLENBROCK, F

机构：

[1] UNIV YORK, DEPT CHEM, YORK YO1 5DD, N YORKSHIRE, ENGLAND

[2] UNIV SALFORD, DEPT BIOL SCI, SALFORD M5 4WT, LANCS, ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1988年 / 256卷 / 02期

关键词：

D O I：

10.1042/bj2560543

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：543 / 555

页数：13

共 50 条

[1] NECESSARY MODIFICATION TO THE PREPARATION OF PAPAIN FROM ANY HIGH-QUALITY LATEX OF CARICA-PAPAYA AND EVIDENCE FOR THE STRUCTURAL INTEGRITY OF THE ENZYME PRODUCED BY TRADITIONAL METHODS
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[2] Baker E. N., 1987, BIOL MACROMOL, V3, P313
[3] BAKER EN, 1981, STRUCTURAL STUDIES M, P339
[4] MAPPING ACTIVE SITE OF PAPAIN WITH AID OF PEPTIDE SUBSTRATES AND INHIBITORS
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[5] BLOW DM, 1986, DESIGN CONSTRUCTION
[6] 18TH KREBS,HANS LECTURE - KNOWLEDGE-BASED PROTEIN MODELING AND DESIGN
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[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 172 (03): : 513 - 520
[7] BODYREV VG, 1966, J ORG CHEM USSR, V2, P91
[8] CONSEQUENCES OF MOLECULAR RECOGNITION IN THE S1-S2 INTERSUBSITE REGION OF PAPAIN FOR CATALYTIC-SITE CHEMISTRY - CHANGE IN PH-DEPENDENCE CHARACTERISTICS AND GENERATION OF AN INVERSE SOLVENT KINETIC ISOTOPE EFFECT BY INTRODUCTION OF A P1-P2 AMIDE BOND INTO A 2-PROTONIC-STATE REACTIVITY PROBEI
BROCKLEHURST, K
KOWLESSUR, D
PATEL, G
TEMPLETON, W
QUIGLEY, K
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WHARTON, CW
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SZAWELSKI, RJ
[J]. BIOCHEMICAL JOURNAL, 1988, 250 (03) : 761 - 772
[9] DIFFERENCES IN THE INTERACTIONS OF THE CATALYTIC GROUPS OF THE ACTIVE-CENTERS OF ACTINIDIN AND PAPAIN - RAPID PURIFICATION OF FULLY ACTIVE ACTINIDIN BY COVALENT CHROMATOGRAPHY AND CHARACTERIZATION OF ITS ACTIVE-CENTER BY USE OF 2-PROTONIC-STATE REACTIVITY PROBES
BROCKLEHURST, K
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[J]. BIOCHEMICAL JOURNAL, 1981, 197 (03) : 739 - 746
[10] REACTIONS OF PAPAIN AND OF LOW-MOLECULAR-WEIGHT THIOLS WITH SOME AROMATIC DISULFIDES - 2,2'-DIPYRIDYL DISULFIDE AS A CONVENIENT ACTIVE-SITE TITRANT FOR PAPAIN EVEN IN PRESENCE OF OTHER THIOLS
BROCKLEHURST, K
LITTLE, G
[J]. BIOCHEMICAL JOURNAL, 1973, 133 (01) : 67 - 80

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