REVISED STRUCTURE OF A TREHALOSE-CONTAINING IMMUNOREACTIVE GLYCOLIPID OF MYCOBACTERIUM-TUBERCULOSIS

被引：51

作者：

LEMASSU, A

LANEELLE, MA

DAFFE, M

机构：

[1] CNRS,CTR RECH BIOCHIM & GENET CELLULAIRES,118 ROUTE NARBONNE,F-31062 TOULOUSE,FRANCE

[2] UNIV TOULOUSE 3,F-31062 TOULOUSE,FRANCE

来源：

FEMS MICROBIOLOGY LETTERS | 1991年 / 78卷 / 2-3期

关键词：

MYCOBACTERIUM-TUBERCULOSIS; ANTIGEN;

D O I：

10.1016/0378-1097(91)90153-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nuclear magnetic resonance spectroscopy, fastatom bombardment mass spectrometry as well as various chemical degradations and chromatographic techniques were used to re-examine the structure of a highly immunoreactive glycolipid previously described in Mycobacterium tuberculosis (strain Canetti) as a 2,3-diacyl trehalose 2'-sulfate (labelled SL-IV). Ion exchange chromatography allowed the recognition of a neutral and an acidic glycolipid, indistinguishable on conventional silica gel. The neutral glycolipid was shown to be serologically identical to SL-IV and its structure was established as 2,3-diacyl trehalose. It corresponded to the non-chemically defined highly observed immunoreactive lipid previously recognized by others in M. tuberculosis (H37Rv).

引用

页码：171 / 176

页数：6

共 19 条

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