PHARMACOKINETIC EVALUATION OF SURFACTANT VESICLE-ENTRAPPED METHOTREXATE IN TUMOR-BEARING MICE

被引：26

作者：

CHANDRAPRAKASH, KS

UDUPA, N

UMADEVI, P

PILLAI, GK

机构：

[1] KASTURBA MED COLL & HOSP,COLL PHARMACEUT SCI,DEPT PHARMACEUT,MANIPAL 576119,INDIA

[2] KASTURBA MED COLL & HOSP,DEPT RADIOBIOL,MANIPAL 576119,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 61卷 / 1-2期

关键词：

Methotrexate; Niosomes; Sarcoma-180 transplantable tumor;

D O I：

10.1016/0378-5173(90)90056-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Methotrexate was encapsulated in niosomes. The entrapment efficiency increased with increase in lipophilicity of surfactant. Unilamellar vesicles prepared with span 60 showed maximum entrapment and its pharmacokinetics in mice transplanted with S-180 tumor was markedly different in comparison to unentrapped methotrexate. © 1990.

引用

页码：R1 / R3

页数：3

共 5 条

[1] A STUDY OF PHOSPHOLIPID INTERACTIONS BETWEEN HIGH-DENSITY LIPOPROTEINS AND SMALL UNILAMELLAR VESICLES [J].