EFFICIENT STEREOSELECTIVE SYNTHESIS OF DOLASTATIN-10, AN ANTINEOPLASTIC PEPTIDE FROM A SEA HARE

被引：51

作者：

HAMADA, Y

HAYASHI, K

SHIOIRI, T

机构：

[1] Faculty of Pharmaceutical Sciences, Nagoya City University Tanabe-dori, Mizuho-ku, Nagoya

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)92123-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective and efficient synthetic route to dolastatin 10, an antineoplastic peptide from a sea hare, has been developed. Dolaproine, one of the unusual constituents, was prepared in a highly stereoselective manner by the Evans aldol methodology.

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页码：931 / 934

页数：4

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