ALTERATION OF VOLTAGE-DEPENDENCE OF SHAKER POTASSIUM CHANNEL BY MUTATIONS IN THE S4-SEQUENCE

被引：451

作者：

PAPAZIAN, DM

TIMPE, LC

JAN, YN

JAN, LY

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM,SAN FRANCISCO,CA 94143

[3] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143

来源：

NATURE | 1991年 / 349卷 / 6307期

关键词：

D O I：

10.1038/349305a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Voltage-dependent potassium, sodium and calcium ion channels may share a common mechanism of activation, in which the conserved S4 sequence acts as the primary voltage sensor. Site-directed mutagenesis of the S4 sequence of the Shaker potassium channel and electrophysiological analysis suggest that voltage-dependent activation involves the S4 sequence but is not solely due to electrostatic interactions.

引用

页码：305 / 310

页数：6

共 41 条

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