DISTRIBUTION OF ALZHEIMERS-DISEASE AMYLOID A4-GENERATING ENZYMES IN RAT-BRAIN TISSUE

被引：19

作者：

ISHIURA, S

NISHIKAWA, T

TSUKAHARA, T

MOMOI, T

ITO, H

SUZUKI, K

SUGITA, H

机构：

[1] AOYAMA GAKUIN UNIV,TOKYO 150,JAPAN

[2] TOKYO METROPOLITAN INST MED SCI,TOKYO 113,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 115卷 / 2-3期

关键词：

Alzheimer's disease; Amyloid; Amyloid A4 protein; Distribution; Proteinase; Rat brain;

D O I：

10.1016/0304-3940(90)90477-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To screen for putative amyloid A4-splitting proteinases, model peptide substrates homologous to the N- and C-terminal portions of the A4 protein were synthesized. The N-terminal A4-splitting enzyme activity was found to be higher in the hypothalamus and limbic area, compared with in the cerebral cortex and cerebellum in 2-month-old rat. The activity decreased throughout the brain in 20-month-old rat. On the other hand, the activity of the putative C-terminal A4-splitting enzyme was significantly higher, 1.4-fold, in the hippocampus than in the cerebral cortex in the young rat. The activity also significantly decreased in the brain of 20-month-old rat, but was still higher in the cerebral cortex, hippocampus and cerebellum. © 1990.

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页码：329 / 334

页数：6

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