HYDROLYSIS PRODUCTS OF CISPLATIN - PKA DETERMINATIONS VIA [H-1, N-15] NMR-SPECTROSCOPY

被引：148

作者：

BERNERSPRICE, SJ

FRENKIEL, TA

FREY, U

RANFORD, JD

SADLER, PJ

机构：

[1] UNIV LONDON,BIRKBECK COLL,DEPT CHEM,GORDON HOUSE,29 GORDON SQ,LONDON WC1H 0PP,ENGLAND

[2] CHRISTOPHER INGOLD LAB,LONDON,ENGLAND

[3] GRIFFITH UNIV,DIV SCI & TECHNOL,NATHAN,QLD 4111,AUSTRALIA

[4] NATL INST MED RES,CTR BIOMED NUCL MAGNET RESONANCE,LONDON NW7 1AA,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 10期

关键词：

D O I：

10.1039/c39920000789

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pK(a) values of cis-[PtCl(H2O)(NH3)2]+ (6.41) and cis-[Pt(H2O)2(NH3)2]2+ (5.37 and 7.21) have been determined at 300 K via the use of N-15-edited H-1 NMR spectroscopy and [H-1, N-15] heteronuclear multiple quantum coherence spectroscopy; this allows rapid measurements at low (millimolar) concentrations, and so avoids some of the problems associated with other methods.

引用

页码：789 / 791

页数：3

共 18 条

[1] NMR-STUDY OF ACID-BASE EQUILIBRIA AND OTHER REACTIONS OF AMMINEPLATINUM COMPLEXES WITH AQUA AND HYDROXO LIGANDS [J].