RAISED PLASMA ENDOTHELIN DURING ACUTE MIGRAINE ATTACK

被引：52

作者：

FARKKILA, M ^{[1
]}

PALO, J ^{[1
]}

SAIJONMAA, O ^{[1
]}

FYHRQUIST, F ^{[1
]}

机构：

[1] UNIV HELSINKI, DEPT MED 4, SF-00290 HELSINKI 29, FINLAND

来源：

CEPHALALGIA | 1992年 / 12卷 / 06期

关键词：

Endothelin; migraine; vasoconstriction;

D O I：

10.1111/j.1468-2982.1992.00383.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Endothelins are the most potent vasoconstrictor peptides known. Plasma endothelin (ET-1) concentrations were measured in eight migraine patients (mean age 44.5 years), two during an acute migraine attack with aura and six during an attack without aura. The mean ET-1 values were elevated in all migraine patients above the range of normal subjects, and were 10.6 (range 6.0-16.0) pg/ml in migraine patients and 3.8 (range 0.7-5.8) pg/ml in controls. We hypothesize that ET-1 may constrict cerebral vessels during the initial stage of the migraine attack.

引用

页码：383 / 384

页数：2

共 9 条

[1] RAISED PLASMA ENDOTHELIN-I CONCENTRATION FOLLOWING COLD PRESSOR TEST
FYHRQUIST, F
SAIJONMAA, O
METSARINNE, K
TIKKANEN, I
ROSENLOF, K
TIKKANEN, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 169 (01) : 217 - 221
[2] ENDOTHELINS
HAMBLIN, TJ
[J]. BRITISH MEDICAL JOURNAL, 1990, 301 (6752) : 568 - 568
[3] PLASMA ENDOTHELIN DURING UPRIGHT TILT - RELEVANCE FOR ORTHOSTATIC HYPOTENSION
KAUFMANN, H
ORIBE, E
OLIVER, JA
[J]. LANCET, 1991, 338 (8782-3) : 1542 - 1545
[4] MASAOKA H, 1989, LANCET, V2, P1402
[5] ENDOTHELIN-1-INDUCED AND ENDOTHELIN-3-INDUCED VASORELAXATION VIA COMMON GENERATION OF ENDOTHELIUM-DERIVED NITRIC-OXIDE
NAMIKI, A
HIRATA, Y
ISHIKAWA, M
MOROI, M
AIKAWA, J
MACHII, K
[J]. LIFE SCIENCES, 1992, 50 (10) : 677 - 682
[6] ISCHEMIA MAY BE THE PRIMARY CAUSE OF THE NEUROLOGIC DEFICITS IN CLASSIC MIGRAINE
OLSEN, TS
FRIBERG, L
LASSEN, NA
[J]. ARCHIVES OF NEUROLOGY, 1987, 44 (02) : 156 - 161
[7] FLUNARIZINE IN PROPHYLAXIS OF CHILDHOOD MIGRAINE - A DOUBLE-BLIND, PLACEBO-CONTROLLED, CROSSOVER STUDY
SORGE, F
DESIMONE, R
MARANO, E
NOLANO, M
OREFICE, G
CARRIERI, P
[J]. CEPHALALGIA, 1988, 8 (01) : 1 - 6
[8] A NOVEL POTENT VASOCONSTRICTOR PEPTIDE PRODUCED BY VASCULAR ENDOTHELIAL-CELLS
YANAGISAWA, M
KURIHARA, H
KIMURA, S
TOMOBE, Y
KOBAYASHI, M
MITSUI, Y
YAZAKI, Y
GOTO, K
MASAKI, T
[J]. NATURE, 1988, 332 (6163) : 411 - 415
[9] PRIMARY STRUCTURE, SYNTHESIS, AND BIOLOGICAL-ACTIVITY OF RAT ENDOTHELIN, AN ENDOTHELIUM-DERIVED VASOCONSTRICTOR PEPTIDE
YANAGISAWA, M
INOUE, A
ISHIKAWA, T
KASUYA, Y
KIMURA, S
KUMAGAYE, SI
NAKAJIMA, K
WATANABE, TX
SAKAKIBARA, S
GOTO, K
MASAKI, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (18) : 6964 - 6967

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