THE PHARMACOEPIDEMIOLOGY OF TREATMENT-REFRACTORY SCHIZOPHRENIA

被引:10
作者
COLLINS, EJ
HOGAN, TP
AWAD, AG
机构
[1] UNIV TORONTO,DEPT PSYCHIAT,TORONTO M5S 1A1,ONTARIO,CANADA
[2] WELLESLEY COLL HOSP,TORONTO M4Y 1J3,ONTARIO,CANADA
来源
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 1992年 / 37卷 / 03期
关键词
D O I
10.1177/070674379203700309
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Treatment-refractory schizophrenia is a major clinical problem for which there is relatively little scientific information, and no consensus has been reached on approaches to treatment. The pharmacotherapy used for 103 patients with a diagnosis of schizophrenia or schizoaffective disorder at one psychiatric hospital was examined. Data were gathered on neuroleptic choice and dose, the use of adjunctive treatment and serum neuroleptic levels. The daily neuroleptic dose was compared with that of random samples of patients receiving outpatient maintenance treatment, and short-stay patients receiving acute treatment. The patients in our sample received high doses of neuroleptics despite a persistent lack of response to treatment, and despite the fact that these were in excess of the recommended maximum beneficial dose. The appropriateness of this therapy is discussed.
引用
收藏
页码:192 / 195
页数:4
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