FOCAL INTRACEREBRAL ELEVATION OF L-LACTATE IS ANTICONVULSANT

被引：6

作者：

FORNAI, F ^{[1
]}

DYBDAL, DJ ^{[1
]}

PROCTOR, MR ^{[1
]}

GALE, K ^{[1
]}

机构：

[1] GEORGETOWN UNIV, MED CTR, DEPT PHARMACOL, 3900 RESERVOIR RD NW, WASHINGTON, DC 20007 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 254卷 / 03期

关键词：

SEIZURE; GLYCOLYSIS; LACTATE;

D O I：

10.1016/0014-2999(94)90473-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sodium lactate (pH 7.0) infused over the area tempestas, an epileptogenic site in the prepiriform cortex, protected rats from limbic motor seizures induced by infusion of a GABA receptor antagonist in area tempestas. The anticonvulsant action, which was anatomically site-specific and reversible, persisted for 90 min. Infusions of sodium acetate (pH 5.5 or 7.0) over area tempestas were not anticonvulsant. Our findings suggest that lactate can modulate neural activity and that increased cerebral lactate as occurs with epileptic seizures, may limit the duration and spread of seizure activity.

引用

页码：R1 / R2

页数：2

共 8 条

[1] NONOXIDATIVE GLUCOSE CONSUMPTION DURING FOCAL PHYSIOLOGIC NEURAL ACTIVITY [J].

FOX, PT ;

RAICHLE, ME ;

MINTUN, MA ;

DENCE, C .

SCIENCE, 1988, 241 (4864) :462-464

[2]

Gale K, 1993, EPILEPSY MODELS MECH, P48

[3] INVIVO IDENTIFICATION AND QUANTITATIVE-EVALUATION OF CARRIER-MEDIATED TRANSPORT OF LACTATE AT THE CELLULAR-LEVEL IN THE STRIATUM OF CONSCIOUS, FREELY MOVING RATS [J].

KUHR, WG ;

VANDENBERG, CJ ;

KORF, J .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1988, 8 (06) :848-856

[4] COMBINED H-1 AND P-31 NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPIC STUDIES OF BICUCULLINE-INDUCED SEIZURES INVIVO [J].

PETROFF, OAC ;

PRICHARD, JW ;

OGINO, T ;

AVISON, M ;

ALGER, JR ;

SHULMAN, RG .

ANNALS OF NEUROLOGY, 1986, 20 (02) :185-193

[5] CEREBRAL LACTATE TURNOVER AFTER ELECTROSHOCK - INVIVO MEASUREMENTS BY H-1/C-13 MAGNETIC-RESONANCE SPECTROSCOPY [J].

PETROFF, OAC ;

NOVOTNY, EJ ;

AVISON, M ;

ROTHMAN, DL ;

ALGER, JR ;

OGINO, T ;

SHULMAN, GI ;

PRICHARD, JW .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1992, 12 (06) :1022-1029

[6] A CRUCIAL EPILEPTOGENIC SITE IN THE DEEP PREPIRIFORM CORTEX [J].

PIREDDA, S ;

GALE, K .

NATURE, 1985, 317 (6038) :623-625

[7] CEREBRAL LACTATE ELEVATION BY ELECTROSHOCK - A H-1 MAGNETIC-RESONANCE STUDY [J].

PRICHARD, JW ;

PETROFF, OAC ;

OGINO, T ;

SHULMAN, RG .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 508 :54-63

[8] ISCHEMICALLY SENSITIVE VISCERAL AFFERENTS - IMPORTANCE OF H+ DERIVED FROM LACTIC-ACID AND HYPERCAPNIA [J].

STAHL, GL ;

LONGHURST, JC .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (03) :H748-H753

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