SENSITIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF AMLODIPINE IN HUMAN PLASMA WITH AMPEROMETRIC DETECTION AND A SINGLE-STEP SOLID-PHASE SAMPLE PREPARATION

被引：53

作者：

JOSEFSSON, M

ZACKRISSON, AL

NORLANDER, B

机构：

[1] Department of Clinical Pharmacology, Faculty of Health Sciences, Linköping University

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 672卷 / 02期

关键词：

D O I：

10.1016/0378-4347(95)00231-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A narrow-bore HPLC assay with electrochemical detection for the determination of the calcium antagonist amlodipine in human plasma samples is presented. By using a single-step solid-phase extraction procedure on Bond Elut C-2 columns, the sample preparation step has been considerably simplified and less time-consuming compared to earlier presented works. With a linear and reproducible calibration curve over the range 0.5-20 ng ml(-1) plasma, the assay has successfully been used in the analysis of more than 500 plasma samples from a multicenter trial.

引用

页码：310 / 313

页数：4

共 3 条

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[2]

MCDOWALL RD, 1994, LC GC EUR, V7, P638

[3] ANALYSIS OF AMLODIPINE IN SERUM BY A SENSITIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD WITH AMPEROMETRIC DETECTION [J].

SHIMOOKA, K ;

SAWADA, Y ;

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