G(Q) AND G(11) ARE CONCURRENTLY ACTIVATED BY BOMBESIN AND VASOPRESSIN IN SWISS 3T3 CELLS

被引：62

作者：

OFFERMANNS, S ^{[1
]}

HEILER, E ^{[1
]}

SPICHER, K ^{[1
]}

SCHULTZ, G ^{[1
]}

机构：

[1] FREE UNIV BERLIN, INST PHARMAKOL, D-14195 BERLIN, GERMANY

来源：

FEBS LETTERS | 1994年 / 349卷 / 02期

关键词：

G-PROTEIN; PHOSPHOLIPASE C; BOMBESIN; VASOPRESSIN;

D O I：

10.1016/0014-5793(94)00667-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha-subunits of the widely expressed G-proteins G(q) and G(11) indistinguishably activate beta-isoforms of phospholipase C. In this report we have tested whether differences exist in the activation of both G-proteins via phospholipase C-linked receptors. We found that bombesin and vasopressin, with very similar potencies and time dependencies, induce the activation of both G(q) and G(11) in Swiss 3T3 cells, suggesting that these G-proteins, at least in part, serve interchangable functions.

引用

页码：201 / 204

页数：4

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