OXIDATION OF NUCLEIC-ACID RELATED-COMPOUNDS BY THE PEROXODISULFATE ION

被引：11

作者：

ITAHARA, T

YOSHITAKE, T

KOGA, S

NISHINO, A

机构：

[1] Institute of Chemistry, College of Liberal Arts, Kagoshima University, Korimoto

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1994年 / 67卷 / 08期

关键词：

D O I：

10.1246/bcsj.67.2257

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The treatment of nucleic acid bases, nucleosides, and nucleotides with peroxodisulfate ion in a phosphate buffer solution at pH 7.0 or water at 70-75-degrees-C was investigated. The reaction of thymine and 5-methylcytosine nucleosides and nucleotides resulted in the oxidation of the 5-methyl groups. The oxidation products from 1,3-dimethyluracils and the time-course of the reaction of uracils led to two plausible reaction mechanisms for the oxidation of uracils.

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页码：2257 / 2264

页数：8

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