BLOOD AND LIVER CYANIDE CONCENTRATIONS IN RATS POISONED WITH ORAL DOSES OF POTASSIUM CYANIDE

被引：12

作者：

EGEKEZE, JO

OEHME, FW

机构：

[1] Comparative Toxicology Laboratory, Kansas State University, Manhattan

来源：

TOXICOLOGY LETTERS | 1979年 / 3卷 / 04期

关键词：

D O I：

10.1016/0378-4274(79)90041-9

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Male rats were employed to study the blood and liver cyanide (CN) concentrations after oral doses of 6, 10 and 14 mg potassium cyanide (KCN)/kg body weight. Animals killed 10 min after administration had higher blood CN concentrations than those killed near death or at survival. The minimum lethal blood CN concentration in rats was found to be in the range 2.60-2.92 μg/ml. Liver CN concentrations were generally lower than the corresponding blood CN concentration for all dosage groups studied. This was probably due to the CN detoxification capability of the liver. Lethal liver CN concentrations were in the range 0.54-6.05 μg/g. © 1979.

引用

页码：243 / 247

页数：5

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