SYNTHESIS AND PRELIMINARY EVALUATION OF AGENTS INCORPORATING THE PHARMACOPHORE OF THE DUOCARMYCIN PYRINDAMYCIN ALKYLATION SUBUNIT - IDENTIFICATION OF THE CC-1065 DUOCARMYCIN COMMON PHARMACOPHORE

被引：136

作者：

BOGER, DL ^{[1
]}

ISHIZAKI, T ^{[1
]}

ZARRINMAYEH, H ^{[1
]}

KITOS, PA ^{[1
]}

SUNTORNWAT, O ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT BIOCHEM,LAWRENCE,KS 66045

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 15期

关键词：

D O I：

10.1021/jo00302a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

: The synthesis of 7 (CI-TMI) incorporating the parent l,2,7,7a-tetrahydrocycloprop[l,2-c]indol-4-one (Cl) alkylation subunit of duocarmycin is described. The results of its comparative evaluation (in vitro cytotoxic activity, DNA covalent alkylation properties) illustrate that 7 (CI-TMI) constitutes an agent bearing the minimum potent pharmacophore of the duocarmycin alkylation subunit and the common pharmacophore of the duocarmycin/CC-1065 alkylation subunits. © 1990, American Chemical Society. All rights reserved.

引用

页码：4499 / 4502

页数：4

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