ADHESION OF HUMAN B-CELLS TO GERMINAL-CENTERS INVITRO INVOLVES VLA-4 AND INCAM-110

被引：289

作者：

FREEDMAN, AS

MUNRO, JM

RICE, GE

BEVILACQUA, MP

MORIMOTO, C

MCINTYRE, BW

RHYNHART, K

POBER, JS

NADLER, LM

机构：

[1] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

[2] BRIGHAM & WOMENS HOSP,DEPT PATHOL,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[4] UNIV TEXAS,MD ANDERSON HOSP & TUMOR INST,CTR CANC,DEPT IMMUNOL,HOUSTON,TX 77030

来源：

SCIENCE | 1990年 / 249卷 / 4972期

关键词：

D O I：

10.1126/science.1697696

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human B lymphocytes localize and differentiate within the microenvironment of lymphoid germinal centers. A frozen section binding assay was developed for the identification of those molecules involved in the adhesive interactions between B cells and lymphoid follicles. Activated human B cells and B cell lines were found to selectively adhere to germinal centers. The VLA4 molecule on the lymphocyte and the adhesion molecule INCAM-110, expressed on follicular dendritic cells, supported this interaction. This cellular interaction model can be used for the study of how B cells differentiate.

引用

页码：1030 / 1033

页数：4

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