ALPHA-1-ACID GLYCOPROTEIN COLUMN IN THE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF SOME GROUPS OF CHIRAL DRUGS

被引：14

作者：

GOROG, S

HERENYI, B

机构：

[1] Chemical Works Gedeon Richter Ltd, H-1475 Budapest

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 8-12期

关键词：

ALPHA-1-ACID GLYCOPROTEIN; CHIRAL HPLC; ENANTIOMERIC SEPARATION; ALPHA-ETHYL BENZHYDROLS; AMINO ACID DERIVATIVES; DILTIAZEM;

D O I：

10.1016/0731-7085(90)80129-D

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The usefulness of the alpha-1-acid glycoprotein (Chiral-AGP) column in the analysis of chiral drugs and related materials is illustrated in three different fields. Excellent separations of the enantiomers of pharmacologically active alpha-ethyl benzhydrols such as 3-trifluoromethyl-alpha-ethyl benzhydrol (flumecinol) and 11 other derivatives are described. The enantiomers of N-protected amino-acid esters or amides can also be separated. The effect of the derivatization of the free alpha-amino group on the resolution of the enantiomers is exemplified by the formylation of alanine benzyl ester. As an example of the use of the method for the estimation of the optical purity of chiral drugs, the determination of the "cis(-)" impurity in "cis(+)" diltiazem is presented.

引用

页码：837 / 842

页数：6

共 25 条

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Allenmark S. G., 1988, CHROMATOGRAPHIC ENAN

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