ISOLATION AND CHARACTERIZATION OF HERPES-SIMPLEX VIRUS RESISTANT TO NUCLEOSIDE ANALOGS

被引：2

作者：

KATZ, E

ROSENBLAT, O

PISANTY, S

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT ORAL DIAG ORAL MED & ORAL RADIOL,POB 1172,IL-91010 JERUSALEM,ISRAEL

[2] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT VIROL,IL-91010 JERUSALEM,ISRAEL

[3] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,FAC DENT MED,DEPT ORAL MED ORAL DIAG & RADIOL,IL-91010 JERUSALEM,ISRAEL

[4] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,FAC DENT MED,DEPT ORAL MED ORAL DIAG & ORAL RADIOL,IL-91010 JERUSALEM,ISRAEL

[5] HEBREW UNIV JERUSALEM,HADASSAH & DENT SCH,JERUSALEM,ISRAEL

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | 1991年 / 72卷 / 03期

关键词：

D O I：

10.1016/0030-4220(91)90218-2

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in BSC1 cells in the presence of 5-iodo-2'-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2'-deoxyuridine and acyclovir and failed to induce significant activity of thymidine kinase in cultures. Herpesvirus reisolated from the same patient 3 1/2 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.

引用

页码：296 / 299

页数：4

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