MACROMOLECULAR DRUGS .2. EFFECTS OF A POLYMER BOUND NICOTINIC-ACID ON EXPERIMENTALLY INDUCED HYPERLIPEMIA IN THE RAT

被引：8

作者：

PUGLISI, L

MAGGI, F

COLLI, S

PAOLETTI, R

机构：

[1] Institute of Pharmacology and Pharmacognosy, University of Milan, 20129 Milan

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1979年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0031-6989(79)80048-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The polymer-bound nicotinic acid (P61) designed as a long-acting form of this well known hypolipidemic drug is devoid of the undesirable side effects which are due to the very high peak level of free nicotinic acid (NA). The effect of this compound has been pharmacologically evaluated both in the plasma lipids and in the liver lipid accumulation in hypercholesterolemic rats. This polymer seems to maintain the activity of the free form of NA on plasma lipids whereas it shows a protective action on TG content in the liver. © 1979 The Italian Pharmacological Society.

引用

页码：775 / 784

页数：10

共 12 条

[1]

ABELL LL, 1952, J BIOL CHEM, V195, P357

[2] INFLUENCE OF NICOTINIC ACID ON SERUM CHOLESTEROL IN MAN [J].

ALTSCHUL, R ;

HOFFER, A ;

STEPHEN, JD .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1955, 54 (02) :558-559

[3]

Carlson L A, 1978, Adv Exp Med Biol, V109, P225

[4]

FOLCH J, 1961, J BIOL CHEM, V236, P1631

[5]

FREDRICKSON DS, 1972, METABOLIC BASIS INHE

[6]

NATH N, 1959, J NUTR, V67, P289

[7] MACROMOLECULAR DRUGS .1. LONG-LASTING ANTILIPOLYTIC ACTIVITY OF NICOTINIC-ACID BOUND TO A POLYMER [J].

PUGLISI, L ;

CARUSO, V ;

PAOLETTI, R ;

FERRUTI, P ;

TANZI, MC .

PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1976, 8 (04) :379-386

[8]

SOLONI FG, 1971, CLIN CHEM, V17, P229

[9] POTENTIATION OF ETHANOL FATTY LIVER IN RATS BY CHRONIC ADMINISTRATION OF NICOTINIC-ACID [J].

SORRELL, MF ;

BAKER, H ;

TUMA, DJ ;

FRANK, O ;

BARAK, AJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 450 (02) :231-238

[10]

SVEDMYR N, 1971, METABOLIC EFFECTS NI

← 1 2 →