INHALED NEBULIZED FENTANYL FOR POSTOPERATIVE ANALGESIA

被引:39
作者
HIGGINS, MJ
ASBURY, AJ
BRODIE, MJ
机构
[1] SO GEN HOSP,DEPT ANAESTHESIA,GLASGOW G51 4TF,SCOTLAND
[2] UNIV GLASGOW,DEPT ANAESTHESIA,GLASGOW G11 6NT,SCOTLAND
[3] UNIV GLASGOW,WESTERN INFIRM,DEPT MED & THERAPEUT,GLASGOW G11 6NT,SCOTLAND
关键词
ANALGESICS; FENTANYL; AEROSOLS; ANALGESIC ADMINISTRATION;
D O I
10.1111/j.1365-2044.1991.tb09862.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The effects of three concentrations of inhaled nebulised fentanyl citrate solution given for postoperative pain relief were studied. Each of 30 patients inhaled one dose of 3 ml of solution nebulised over 9 min. A combined analysis of pain relief, time to further analgesia and effect on respiratory frequency showed the highest concentration (318 μg/ml fentanyl base) to be more effective (p < 0.01) than the two lower concentrations (159 μg/ml and 64 μg/ml) which were indistinguishable from each other. There were no major side effects. This study provides evidence for the efficacy and safety of inhaled fentanyl for postoperative analgesia. Estimation of the delivered doses did not support the hypothesis that fentanyl is more effective by this route compared with other parenteral routes. Further studies are required to improve the method of delivery and investigate the pharmacodynamic features of this technique. Copyright © 1991, Wiley Blackwell. All rights reserved
引用
收藏
页码:973 / 976
页数:4
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