CI-960 (PD127391 OR AM-1091), SPARFLOXACIN, WIN-57273, AND ISEPAMICIN ACTIVITY AGAINST CLINICAL ISOLATES OF MYCOBACTERIUM-AVIUM-INTRACELLULARAE COMPLEX, M-CHELONAE, AND M-FORTUITUM

被引:10
作者
BARRETT, MS
JONES, RN
ERWIN, ME
KOONTZ, FP
机构
[1] UNIV IOWA HOSP & CLIN,DEPT PATHOL,ANTIINFECT RES CTR,IOWA CITY,IA 52242
[2] DEPT VET AFFAIRS MED CTR,IOWA CITY,IA
[3] UNIV IOWA HOSP & CLIN,DEPT PATHOL,CLIN MICROBIOL LAB,IOWA CITY,IA 52242
关键词
D O I
10.1016/0732-8893(92)90044-T
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
A 7119 broth microdilution method against CI-960, sparfloxacin, WIN57273, ciprofloxacin, norfloxacin, isepamicin, amikacin, kanamycin, ethambutol, isoniazid, and rifampin was used to test 35 Mycobacterium avium-intracellulare complex (MAI) and five M. chelonae-fortuitum strains. The majority of MAI isolates were inhibited by all tested compounds, with sparfloxacin (MIC90, 0.5-mu-g/ml) being the most active among the fluoroquinolones: isepamicin (MIC90, 4-mu-g/ml), the most potent aminoglycoside; and isoniazid, rafampin, and ethambutol also demonstrating some degree of activity. Mycobacterium chelonae strains were resistant to all drugs except ciprofloxacin (MIC50, 1-mu-g/ml). Mycobacterium fortuitum isolates were generally susceptible, especially to the newer fluoroquinolones.
引用
收藏
页码:169 / 171
页数:3
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