POLYMERIC PSEUDOLATTICES BEARING PILOCARPINE FOR CONTROLLED OCULAR DELIVERY

被引：13

作者：

VYAS, SP

RAMCHANDRAIAH, S

JAIN, CP

JAIN, SK

机构：

[1] Pharmaceutics Laboratories, Department of Pharmaceutical Sciences, Dr Harisingh Gour Vishwavidyalaya, Sagar, 470 003, MP

来源：

JOURNAL OF MICROENCAPSULATION | 1992年 / 9卷 / 03期

关键词：

D O I：

10.3109/02652049209021249

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The pseudolatex-based ocular formulations of pilocarpine were prepared using different combinations of Eudragit RS 100 and polyvinyl pyrrolidone for prolonged and controlled release of the drug. The designed system was essentially based on polymeric pseudolatex dispersion. The process variables that effect the latex particle size, drug loading and release profiles of drug were studied. Preparations were evaluated for their in vitro performance with regard to release profile and diffusion co-efficient. The designed system exhibited linear relationship between cumulative drug release (Q) and square root of time (t0.5). The products selected on the basis of in vitro characterization were studied for in vivo performance evaluation. It was observed that the preparations exhibited in vivo prolonged therapeutic efficacy. Thus polymer based pseudolatices hold promise for controlled pilocarpine ocular delivery.

引用

页码：347 / 355

页数：9

共 22 条

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