HYPERCALCEMIC CRISIS AFTER EXCESSIVE TOPICAL USE OF A VITAMIN-D DERIVATIVE

被引:19
作者
HOECK, HC [1 ]
LAURBERG, G [1 ]
LAURBERG, P [1 ]
机构
[1] AALBORG HOSP,DEPT INTERNAL MED & ENDOCRINOL,DK-9000 AALBORG,DENMARK
关键词
CALCIPOTRIOL; HYPERCALCEMIA; ICHTHYOSIS; TOPICAL USE; VITAMIN D;
D O I
10.1111/j.1365-2796.1994.tb01074.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Topical application of the vitamin D analogue calcipotriol has been found to be of clinical value in the treatment of dermatological disorders. This is considered to be safe with respect to alterations in calcium homeostasis. We report a 17-year-old female patient who developed hypercalcaemic crisis after excessive use of calcipotriol for ichthyosis. The clinical condition and serum calcium improved after cessation of calciprotiol treatment and rehydration with intravenous fluids and electrolytes. The case emphasizes the importance of limiting the topical use of calcipotriol as recommended by the manufacturer.
引用
收藏
页码:281 / 282
页数:2
相关论文
共 6 条
[1]   VITAMIN-D ANALOGS AND PSORIASIS [J].
BERTHJONES, J ;
HUTCHINSON, PE .
BRITISH JOURNAL OF DERMATOLOGY, 1992, 127 (02) :71-78
[2]   EFFECTS OF A NOVEL VITAMIN-D ANALOG MC-903 ON CELL-PROLIFERATION AND DIFFERENTIATION INVITRO AND ON CALCIUM-METABOLISM INVIVO [J].
BINDERUP, L ;
BRAMM, E .
BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) :889-895
[3]   CALCIPOTRIOL AND HYPERCALCEMIA [J].
DWYER, C ;
CHAPMAN, RS .
LANCET, 1991, 338 (8769) :764-765
[4]   CALCIPOTRIOL (MC-903) - PHARMACOKINETICS IN RATS AND BIOLOGICAL-ACTIVITIES OF METABOLITES - A COMPARATIVE-STUDY WITH 1,25(OH)2D3 [J].
KISSMEYER, AM ;
BINDERUP, L .
BIOCHEMICAL PHARMACOLOGY, 1991, 41 (11) :1601-1606
[5]  
KRAGBALLE K, 1991, ACTA DERM-VENEREOL, V71, P475
[6]   VITAMIN-A TOXICITY AND HYPERCALCEMIA [J].
RAGAVAN, VV ;
SMITH, JE ;
BILEZIKIAN, JP .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1982, 283 (03) :161-164