A 2 STEP BIOMIMETIC TOTAL SYNTHESIS OF EILATIN

被引：22

作者：

GELLERMAN, G ^{[1
]}

BABAD, M ^{[1
]}

KASHMAN, Y ^{[1
]}

机构：

[1] TEL AVIV UNIV,SCH CHEM,IL-69978 TEL AVIV,ISRAEL

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(00)60790-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The symmetrical tetraaza heptacyclic alkaloid eilatin (1) was synthesized in a biomimetic two step reaction from catechol and monotrifluoro kynuramine (6) under oxidative conditions in the first step (aq, EtOH, NaIO3) and basic conditions (ammoniacal MeOH, DMAP) in the second. Two other unsuccessful approaches, one leading to 7-phenylascididemin, are described.

引用

页码：1827 / 1830

页数：4

共 6 条

[1]

CADOGEN JI, 1968, Q REV, V22, P122

[2]

GELLERMAN G, TET LETT

[3] ASCIDIDEMIN, A NOVEL PENTACYCLIC AROMATIC ALKALOID WITH POTENT ANTILEUKEMIC ACTIVITY FROM THE OKINAWAN TUNICATE DIDEMNUM SP [J].