EFFECT OF TRANSCUTANEOUS ELECTRICAL NERVE-STIMULATION ON CORONARY BLOOD-FLOW

被引:87
作者
CHAUHAN, A
MULLINS, PA
THURAISINGHAM, SI
TAYLOR, G
PETCH, MC
SCHOFIELD, PM
机构
[1] Regional Cardiac Unit, Papworth Hospital, Papworth Everard, Cambridge
关键词
TRANSPLANTATION; CORONARY DISEASE; NOREPINEPHRINE;
D O I
10.1161/01.CIR.89.2.694
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Although neurostimulation has been shown to be of benefit in angina pectoris, the exact mechanism of its action is not clear. This study was performed to examine the effect of transcutaneous electrical nerve stimulation on coronary blood flow. Methods and Results The effect of transcutaneous electrical nerve stimulation was studied in 34 syndrome X patients (group 1), 15 coronary artery disease patients (group 2), and 16 heart transplant patients (group 3). Coronary blood flow velocity (CBFV) in the left coronary system was measured at rest and after a 5-minute stimulation period with a Judkins Doppler. There was a significant increase in the resting CBFV in group 1 (from 6.8+/-4.1 to 10.5+/-5.7 cm/s, P<.001) and group 2 (from 6.8+/-4.1 to 10.5+/-5.7 cm/s, P<.001). However, there was no significant change in the resting CBFV in group 3. There were no significant changes in the coronary arterial diameters as a result of neurostimulation. There was a significant decrease in the epinephrine levels in group 1 (from 79.6+/-17.8 to 58.5+/-17.5 ng/L, P=.01) and group 2 (from 102.2+/-27.2 to 64.1+/-19.1 ng/L, P=.01). Conclusions Transcutaneous electrical nerve stimulation can increase resting coronary blood flow velocity. The findings suggest that the site of action is at the microcirculatory level and that the effects may be mediated by neural mechanisms.
引用
收藏
页码:694 / 702
页数:9
相关论文
共 42 条
[1]   EPIDURAL ELECTRICAL-STIMULATION IN SEVERE LIMB ISCHEMIA - PAIN RELIEF, INCREASED BLOOD-FLOW, AND A POSSIBLE LIMB-SAVING EFFECT [J].
AUGUSTINSSON, LE ;
CARLSSON, CA ;
HOLM, J ;
JIVEGARD, L .
ANNALS OF SURGERY, 1985, 202 (01) :104-110
[2]  
CHAUHAN A, 1993, BRIT HEART J, V69, P516
[3]   VALIDATION-STUDY OF A DOPPLER-TIPPED ANGIOGRAPHIC CATHETER FOR MEASUREMENT OF CORONARY FLOW RESERVE [J].
CHAUHAN, A ;
MULLINS, P ;
THURAISINGHAM, S ;
TAYLOR, G ;
PETCH, M ;
SCHOFIELD, P .
AMERICAN JOURNAL OF CARDIOLOGY, 1993, 71 (12) :1119-1121
[4]  
CREA F, 1989, LANCET, V1, P683
[5]   CATECHOLAMINE METABOLISM DURING PACING-INDUCED ANGINA-PECTORIS AND THE EFFECT OF TRANS-CUTANEOUS ELECTRICAL NERVE-STIMULATION [J].
EMANUELSSON, H ;
MANNHEIMER, C ;
WAAGSTEIN, F ;
WILHELMSSON, C .
AMERICAN HEART JOURNAL, 1987, 114 (06) :1360-1366
[6]   AFFERENT-FIBERS MEDIATE THE INCREASE OF MET-ENKEPHALIN ELICITED IN RAT SPINAL-CORD BY LOCALIZED PAIN [J].
FACCINI, E ;
UZUMAKI, H ;
GOVONI, S ;
MISSALE, C ;
SPANO, PF ;
COVELLI, V ;
TRABUCCHI, M .
PAIN, 1984, 18 (01) :25-31
[7]  
FRAYN KN, 1983, CLIN CHEM, V29, P1426
[8]  
FRIEDMAN H, 1974, ADV NEUROL, V4, P769
[9]   QUANTITATIVE ANGIOGRAPHY - MEASUREMENT OF CORONARY VASOMOBILITY IN INTACT ANIMAL AND MAN [J].
GENSINI, GG ;
KELLY, AE ;
DACOSTA, BCB ;
HUNTINGTON, PP .
CHEST, 1971, 60 (06) :522-+
[10]   PHYSIOLOGIC BASIS FOR ASSESSING CRITICAL CORONARY STENOSIS - INSTANTANEOUS FLOW RESPONSE AND REGIONAL DISTRIBUTION DURING CORONARY HYPEREMIA AS MEASURES OF CORONARY FLOW RESERVE [J].
GOULD, KL ;
LIPSCOMB, K ;
HAMILTON, GW .
AMERICAN JOURNAL OF CARDIOLOGY, 1974, 33 (01) :87-94