LONG-TERM TREATMENT OF BENIGN PROSTATIC HYPERPLASIA WITH ALFUZOSIN - A 12-18 MONTH ASSESSMENT

被引:41
作者
JARDIN, A
BENSADOUN, H
DELAUCHECAVALLIER, MC
ATTALI, P
机构
[1] SYNTHELABO RECH,LERS,SERV MED INTERNE,31 AVE PAUL VAILLANT COUTURIER,BP 110,F-92225 BAGNEUX,FRANCE
[2] HOP BICETRE,DEPT UROL,F-94270 LE KREMLIN BICETR,FRANCE
来源
BRITISH JOURNAL OF UROLOGY | 1993年 / 72卷 / 05期
关键词
D O I
10.1111/j.1464-410X.1993.tb16220.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
In order to assess the efficacy and safety of alfuzosin, an alpha-1 blocker, in symptomatic patients with benign prostatic hyperplasia (BPH), 131 patients who had completed a 6-month placebo-controlled trial conducted on parallel groups entered a 12-month open study; 122 patients were treated with alfuzosin for 12 months and 56 patients for 18 months. After 12 months, all obstructive and irritative symptoms assessed according to the Boyarsky scale were significantly improved, as were peak flow rates in obstructed patients and mean flow rates and residual urine in the whole population. Voiding symptoms showed sustained improvement after treatment for 12 to 18 months. Only 5.3% of patients experienced vasodilatory side effects, none of which led to withdrawal from the study. No side effect related to long-term administration was reported. Alfuzosin has a beneficial effect on voiding symptoms in patients with BPH and can be safely used in long-term administration.
引用
收藏
页码:615 / 620
页数:6
相关论文
共 17 条
[1]   BLADDER OUTFLOW OBSTRUCTION TREATED WITH PHENOXYBENZAMINE [J].
ABRAMS, PH ;
SHAH, PJR ;
STONE, R ;
CHOA, RG .
BRITISH JOURNAL OF UROLOGY, 1982, 54 (05) :527-530
[2]   THE NATURAL-HISTORY OF UNTREATED PROSTATISM [J].
BALL, AJ ;
FENELEY, RCL ;
ABRAMS, PH .
BRITISH JOURNAL OF UROLOGY, 1981, 53 (06) :613-616
[3]  
Boyarsky S, 1976, Trans Am Assoc Genitourin Surg, V68, P29
[4]   PLACEBO-CONTROLLED DOUBLE-BLIND-STUDY OF EFFECT OF PHENOXYBENZAMINE IN BENIGN PROSTATIC OBSTRUCTION [J].
CAINE, M ;
PERLBERG, S ;
MERETYK, S .
BRITISH JOURNAL OF UROLOGY, 1978, 50 (07) :551-554
[5]  
CAVERO I, 1985, British Journal of Pharmacology, V86, p416P
[6]   A 12-WEEK PLACEBO-CONTROLLED STUDY OF PRAZOSIN IN THE TREATMENT OF PROSTATIC OBSTRUCTION [J].
CHAPPLE, CR ;
CHRISTMAS, TJ ;
MILROY, EJG .
UROLOGIA INTERNATIONALIS, 1990, 45 :47-55
[7]   MULTICENTER CONTROLLED TRIAL OF INDORAMIN IN THE SYMPTOMATIC RELIEF OF BENIGN PROSTATIC HYPERTROPHY [J].
CHOW, W ;
HAHN, D ;
SANDHU, D ;
SLANEY, P ;
HENSHAW, R ;
DAS, G ;
WELLS, P .
BRITISH JOURNAL OF UROLOGY, 1990, 65 (01) :36-38
[8]  
CHRISTMAS TJ, 1991, WORLD J UROL, V9, P36
[9]   BLADDER-NECK OPENING TEST IN SPINAL-CORD INJURY PATIENTS USING A NEW IV ALPHA-BLOCKING AGENT, ALFUZOSIN [J].
CRAMER, P ;
NEVEUX, E ;
REGNIER, F ;
DEPASSIO, J ;
BERARD, E .
PARAPLEGIA, 1989, 27 (02) :119-124
[10]  
FABRICIUS PG, 1990, PROSTATE, V3, P85