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SOLID-STATE NMR AND IR FOR THE ANALYSIS OF PHARMACEUTICAL SOLIDS - POLYMORPHS OF FOSINOPRIL SODIUM

被引：45
作者：
BRITTAIN, HG
MORRIS, KR
BUGAY, DE
THAKUR, AB
SERAJUDDIN, ATM
机构：
[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, New Brunswick, NJ 08903
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 11-12期
基金：
美国国家科学基金会;
关键词：
FOSINOPRIL SODIUM; POLYMORPHISM; INFRARED SPECTROSCOPY; SOLID STATE C-13- AND P-31-NMR; THERMAL ANALYSIS; POWDER X-RAY DIFFRACTION;
D O I：
10.1016/0731-7085(93)80083-D
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The two polymorphic modifications of fosinopril sodium have been characterized as to their differences in melting behaviour, powder X-ray diffraction patterns, Fourier transform infrared spectra (FTIR), and solid-state P-31- and C-13-NMR spectra. The polymorphs were found to be enantiotropically related based upon melting point, heat of fusion, and solution mediated transformation data. Analysis of the solid-state FTIR and C-13-NMR data indicated that the environment of the acetal side chain of fosinopril sodium differed in two polymorphs, and that there might be cis-trans isomerization about the C-6-N peptide bond. These conformational differences are postulated as the origin of the observed polymorphism.
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页码：1063 / 1069
页数：7
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