LEUKOTRIENE-D4 - A POTENT CORONARY-ARTERY VASOCONSTRICTOR ASSOCIATED WITH IMPAIRED VENTRICULAR CONTRACTION

被引：254

作者：

MICHELASSI, F

LANDA, L

HILL, RD

LOWENSTEIN, E

WATKINS, WD

PETKAU, AJ

ZAPOL, WM

机构：

[1] HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT ANESTHESIA, BOSTON, MA 02115 USA

[3] MASSACHUSETTS GEN HOSP, SURG SERV, BOSTON, MA 02114 USA

来源：

SCIENCE | 1982年 / 217卷 / 4562期

关键词：

D O I：

10.1126/science.6808665

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Leukotriene D4 (2 .times. 10-9 mol), injected into the left circumflex coronary artery of anesthetized sheep, produced profound coronary vasoconstriction and impaired regional ventricular wall motion. This [anaphylactic] cardiac effect was neither inhibited by prior treatment of the sheep with a cyclooxygenase inhibitor [ibuprofen] nor associated with thromboxane B2 release into the coronary sinus. I.v. FPL 55712 completely abolished the coronary vasoconstriction of leukotriene D4, but a significant reduction of regional wall shortening persisted.

引用

页码：841 / 843

页数：3

共 15 条

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