DELAYED-HYPERSENSITIVITY IN MAN - EFFECTS OF SYSTEMIC ANTICOAGULATION

被引:123
作者
EDWARDS, RL [1 ]
RICKLES, FR [1 ]
机构
[1] VET ADM HOSP,NEWINGTON,CT 06111
关键词
D O I
10.1126/science.644314
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Skin test reactivity, lymphocyte transformation, and mononuclear cell tissue factor generation were evaluated both before and during systemic anticoagulation in 24 volunteers. Anticoagulation with warfarin decreased skin test induration and tissue factor generation, but lymphocyte transformation remained unchanged. An intact coagulation mechanism, including tissue factor generation, appears to be important for the development of skin test induration in humans. Copyright © 1978 AAAS.
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页码:541 / 543
页数:3
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