TYROSINE HYDROXYLASE INHIBITION IN VITRO AND IN VIVO BY CHELATING AGENTS

被引：48

作者：

TAYLOR, RJ

STUBBS, CS

ELLENBOGEN, L

机构：

[1] Lederle Laboratories, American Cyanamid Company, Pearl River

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 03期

关键词：

D O I：

10.1016/0006-2952(69)90083-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A variety of metal chelating agents inhibited bovine adrenal tyrosine hydroxylase in vitro. Bipyridyl, o-phenanthroline, TPTZ (2,4,6-tripyridyl-s-triazine) and bathophenanthroline (4,7-diphenyl-1,10-phenanthroline), which have high affinities for divalent iron, were the most effective inhibitors. Inhibition by o-phenanthroline was noncompetitive with tyrosine or pteridine cofactor, but dependent on iron concentration. Bipyridyl, administered to rats, inhibited adrenal tyrosine hydroxylase activity and markedly lowered adrenal, heart and brain catecholamines. © 1969.

引用

页码：587 / +

页数：1

共 17 条

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