IMMUNOSUPPRESSION BY A MOUSE-TUMOR RESEMBLES ANTIGENIC-COMPETITION

被引：5

作者：

COCITO, CG

MICHOT, B

RADOVICH, J

TALMAGE, DW

机构：

[1] UNIV COLORADO,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80262

[2] UNIV COLORADO,MED CTR,WEBB WARING LUNG INST,DENVER,CO 80262

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 06期

关键词：

D O I：

10.1073/pnas.76.6.2895

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The intraperitoneal injection of γ-radiated, UV-radiated, or unradiated P-815 tumor cells into syngeneic or allogeneic mice suppressed the immune response to a subsequent intraperitoneal injection of sheep erythrocytes in a manner similar to the suppression caused by the injection of horse erythrocytes and termed antigenic competition. In both cases, the greatest suppression occurred when the sheep erythrocytes were injected at the same site (intraperitoneal) as the tumor or antigen several days after the tumor or antigen and in a dose of 108 erythrocytes or less.

引用

页码：2895 / 2897

页数：3

共 10 条

[1] DEPRESSED CELL-MEDIATED IMMUNITY IN PATIENTS WITH PRIMARY INTRACRANIAL TUMORS - CHARACTERIZATION OF A HUMORAL IMMUNOSUPPRESSIVE FACTOR [J].