BLOCKADE OF MORPHINE ANALGESIA BY BOTH PERTUSSIS AND CHOLERA TOXINS IN THE PERIAQUEDUCTAL GRAY AND LOCUS-CERULEUS

被引：35

作者：

BODNAR, RJ

PAUL, D

ROSENBLUM, M

LIU, L

PASTERNAK, GW

机构：

[1] MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,COTZIAS LABNEUROONCOL,1275 YORK AVE,NEW YORK,NY 10021

[2] CORNELL UNIV,MED CTR,COLL MED,DEPT PHARMACOL,NEW YORK,NY 10021

[3] MEM SLOAN KETTERING CANC CTR,DEPT NEUROPATHOL,NEW YORK,NY 10021

[4] CORNELL UNIV,MED CTR,COLL MED,DEPT NEUROL,NEW YORK,NY 10021

来源：

BRAIN RESEARCH | 1990年 / 529卷 / 1-2期

关键词：

Cholera toxin; G-protein; Morphine analgesia; Pertussis toxin;

D O I：

10.1016/0006-8993(90)90845-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats demonstrating analgesia following microinjection of morphine into the periaqueductal gray (PAG) or locus coeruleus (LC) were injected with either pertussis toxin, cholera toxin or saline into the same brain region. Both pertussis and cholera toxin blocked the analgesic effect of morphine at both injection sites for up to 7 days after toxin treatment. These results indicate that morphine analgesia is a complex response involving systems dependent upon Gs as well as Gi of Go proteins. © 1990.

引用

页码：324 / 328

页数：5

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