EFFECTS OF THE ANTIDEPRESSANT PHENELZINE ON BRAIN LEVELS OF GAMMA-AMINOBUTYRIC-ACID (GABA)

被引：65

作者：

BAKER, GB ^{[1
]}

WONG, JTF ^{[1
]}

YEUNG, JM ^{[1
]}

COUTTS, RT ^{[1
]}

机构：

[1] UNIV ALBERTA,PMHAC RES UNIT,EDMONTON T6G 2E1,ALBERTA,CANADA

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1991年 / 21卷 / 03期

基金：

英国医学研究理事会;

关键词：

GAMMA-AMINOBUTYRIC ACID (GABA); ANTIDEPRESSANTS; MONOAMINE OXIDASE (MAO); PANIC DISORDER; PHENELZINE;

D O I：

10.1016/0165-0327(91)90041-P

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Time- and dose-response studies were carried out on the effects of the monoamine oxidase-inhibiting antidepressant and antipanic drug phenelzine on GABA levels in rat whole brain. At a dose of 15 mg/kg i.p., phenelzine significantly elevated GABA levels at all time intervals studied (1, 2, 4, 8, 16, and 24 h). A further investigation indicated that this was a dose-dependent effect. The possible importance of GABA in the etiology and pharmacotherapy of depression and panic disorder is discussed.

引用

页码：207 / 211

页数：5

共 23 条

[1]

BAKER GB, 1989, SOC NEUR ABSTR, V37, P853

[2]

BALLENGER JC, 1986, J CLIN PSYCHIAT, V47, P27

[3]

BRESLOW MF, 1989, AM J PSYCHIAT, V146, P353

[4] BRAIN GABA A BENZODIAZEPINE BINDING-SITES AND GLUTAMIC-ACID DECARBOXYLASE ACTIVITY IN DEPRESSED SUICIDE VICTIMS [J].

CHEETHAM, SC ;

CROMPTON, MR ;

KATONA, CLE ;

PARKER, SJ ;

HORTON, RW .

BRAIN RESEARCH, 1988, 460 (01) :114-123

[5] ARE INCREASES IN GABA-B RECEPTORS CONSISTENT FINDINGS FOLLOWING CHRONIC ANTIDEPRESSANT ADMINISTRATION [J].

CROSS, JA ;

HORTON, RW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 141 (01) :159-162

[6] EFFECTS OF CHRONIC ORAL-ADMINISTRATION OF THE ANTIDEPRESSANTS, DESMETHYLIMIPRAMINE AND ZIMELIDINE ON RAT CORTICAL GABAB BINDING-SITES - A COMPARISON WITH 5-HT2 BINDING-SITE CHANGES [J].

CROSS, JA ;

HORTON, RW .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (02) :331-336

[7] BRAIN GABAB BINDING-SITES IN DEPRESSED SUICIDE VICTIMS [J].

CROSS, JA ;

CHEETHAM, SC ;

CROMPTON, MR ;

KATONA, CLE ;

HORTON, RW .

PSYCHIATRY RESEARCH, 1988, 26 (02) :119-129

[8] GABA CONCENTRATIONS IN FOREBRAIN AREAS OF SUICIDE VICTIMS [J].

KORPI, ER ;

KLEINMAN, JE ;

WYATT, RJ .

BIOLOGICAL PSYCHIATRY, 1988, 23 (02) :109-114

[9] THE GABAERGIC HYPOTHESIS OF DEPRESSION [J].

LLOYD, KG ;

ZIVKOVIC, B ;

SCATTON, B ;

MORSELLI, PL ;

BARTHOLINI, G .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1989, 13 (3-4) :341-351

[10]

LLOYD KG, 1985, J PHARMACOL EXP THER, V235, P191

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